There are many common problems in the preparation of injections, but the impact of these minor problems is very great. The summary is summarized as follows:
1, PH value adjustment
First, in the actual production process, the regulation of ph is very common. In many national standards, the pH range is very wide, but actually every medicine is actually only one or more of each medicine in its most suitable dosage form. Point, then you need to find this point, which has a lot to improve stability. For example, the ingredients in many traditional Chinese medicines or biochemicals are not simply simple substances but a complex system. Therefore, the most appropriate PH of these ingredients is not the same. This is more than the pros and cons of finding the ideal state you need.
Second, the ph of injections is constantly changing in different aspects of your preparation, sterilization, etc. What we often do is to add some buffer pairs. We often do is add some buffer pairs, and we can also find the real changes. For reasons, you can also find the real reason for the change so that the controller can change in many ways.
2. Cleaning of industrial equipment for injections
The heat source of injections has always been a common problem. In fact, it is a good solution. If there are no problems with the raw materials, then the reason is on the tools and equipment. On-line sterilization is a good way. If you use a lye, it is better. This is known to everybody, but the order of the two requires careful thought. Because many biological substances are online and are not cleaned in time, the body will form a source of pollution, and then you will clean it again. It is difficult and often requires passivation, which is a great damage to the equipment. Small appliances are often disassembled and cleaned just fine.
3, the uniformity of the liquid
The homogeneity of the liquid is often mentioned, but here we focus on the influence of the preparation process, and the effect on the heterogeneity of the finished product is certain. However, what is often overlooked is that it will be tested as your intermediate. Inaccurate, unable to accurately guide the next production, but also cause the PH and other indicators inaccurate, often do a little verification.
Comment on two points:
1. Whether or not the pH is correct is the key to some injections. Some products, PH up and down 0.2, can cause heavy metals to fail.
2. An example of buffer pH adjustment - Houttuynia injection ensures the stability of PH.
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