He Fuchu group found that an immune regulatory protein is expected to become a hepatitis special drug

Release date: 2009-08-21

The National Key Laboratory of Proteomics (Beijing Proteome Research Center), led by He Fuchu, dean of the Academy of Military Medical Sciences and academician of the Chinese Academy of Sciences, discovered an important immunoregulatory protein LSECtin (sinusoidal endothelial cell C-type lectin) in the liver. ). LSECtin is the first immunomodulatory molecule that has been specifically expressed by scientists in the liver, and is a new functional protein with complete intellectual property rights. It may develop into a special drug for the treatment of hepatic inflammatory diseases. Recently, this important result was published online by the professional journal Gastroenterology in the field of digestive diseases research. The liver is an important metabolic and detoxifying organ in the human body. In recent years, scientists have gradually realized that the liver is also an important immune organ, which can promptly remove inflammatory cells that continuously circulate from the blood to the liver, and prevent inflammatory cells from causing pathological damage to the human body. Who is fulfilling this important mission in the liver? Academician He Fuchu led Dr. Tang Li and Dr. Yang Juntao and other researchers to find out the true elimination of these inflammatory cells in the liver after six years of painstaking exploration and research on the basis of large-scale exploration of new genes and new proteins of human fetal liver. One of the heroes, LSECtin. Dr. Tang Li said: "LSECtin can selectively recognize activated inflammatory cells, effectively stop their reproduction and inhibit their production of inflammatory factors. We use the most advanced gene knockout technology to completely remove LSECtin from the animal body and discover the body. The inflammatory cells will increase significantly, and the inflammatory factors will increase sharply. This important research has laid an important foundation for further enriching the 'liver immunology' theory." It is reported that the academician team of He is giving acute autoimmunity After injection of LSECtin into animals with hepatitis, it was found that the inflammatory factors in the liver were significantly reduced, the liver tissue damage was alleviated, and the transaminase was decreased, showing a significant therapeutic effect. It can be speculated that LSECtin is likely to develop into a special drug for the treatment of liver inflammatory diseases.
——Midi Medical Network

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