Most cases of cancer deaths are caused by the spread of cancer cells to vital organs such as the liver or brain.
According to the report of the British "Daily Mail" on December 7, scientists from the Cancer Research Center in Lausanne, Switzerland, recently discovered a "primary" protein called Periostin that promotes the proliferation and metastasis of tumors. Experiments have shown that controlling the amount of this protein can effectively inhibit the activity of malignant tumors (cancer cells). Therefore, this discovery will hopefully open up a whole new path for cancer treatment.
Osteoblast specific factor-2 is an extracellular matrix protein that is normally present in the connective tissue gaps between cells and plays an important role in the formation of fetal bone. The research team leader Dr. Jörg Hulsman said that the researchers discovered the above-mentioned effects of osteoblast specific factor 2 when simulating the survival environment of tumors.
“My colleagues have simulated several situations that are suitable for tumor survival and facilitate the spread of tumors to form cancer cells. It was found that this particular protein plays a very important role in the spread of malignancy,†Dr. Jörg said. “If not With this protein's 'transport function', cancer cells will not spread smoothly and will remain dormant. That is, if we can control the activity of this protein, it is expected to inhibit the further spread and deterioration of cancer cells."
Scientists have begun to develop antibodies based on this finding that can attach to the outer wall of the protein and cause its dysfunction, and hope that this antibody can help humans fight cancer.
"An animal experiment proves that our treatment is workable and does not produce too many side effects. Although, this does not mean that this antibody is equally effective for humans, and we are not sure that we can find similar antibodies that are effective against humans. But we are working hard," said Dr. Jörg.
According to the report of the British "Daily Mail" on December 7, scientists from the Cancer Research Center in Lausanne, Switzerland, recently discovered a "primary" protein called Periostin that promotes the proliferation and metastasis of tumors. Experiments have shown that controlling the amount of this protein can effectively inhibit the activity of malignant tumors (cancer cells). Therefore, this discovery will hopefully open up a whole new path for cancer treatment.
Osteoblast specific factor-2 is an extracellular matrix protein that is normally present in the connective tissue gaps between cells and plays an important role in the formation of fetal bone. The research team leader Dr. Jörg Hulsman said that the researchers discovered the above-mentioned effects of osteoblast specific factor 2 when simulating the survival environment of tumors.
“My colleagues have simulated several situations that are suitable for tumor survival and facilitate the spread of tumors to form cancer cells. It was found that this particular protein plays a very important role in the spread of malignancy,†Dr. Jörg said. “If not With this protein's 'transport function', cancer cells will not spread smoothly and will remain dormant. That is, if we can control the activity of this protein, it is expected to inhibit the further spread and deterioration of cancer cells."
Scientists have begun to develop antibodies based on this finding that can attach to the outer wall of the protein and cause its dysfunction, and hope that this antibody can help humans fight cancer.
"An animal experiment proves that our treatment is workable and does not produce too many side effects. Although, this does not mean that this antibody is equally effective for humans, and we are not sure that we can find similar antibodies that are effective against humans. But we are working hard," said Dr. Jörg.
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