Release date: 2016-05-05
Monash University and international researchers have discovered that a protein is associated with 90% of the development of colorectal cancer, which also affects the development of several other cancers, including breast and liver cancer.
The study, published in the journal Developmental Cytology, was led by Professor Colby Zaph from Monash University's Biomedical Research Institute and was completed by researchers from Australia, Japan, the United States, and Canada.
The study focused on the SETD7 protein, an enzyme that can modify other proteins to affect their function. SETD7 plays a central regulatory role in two important pathways of tumorigenesis. These two pathways are the Hippo/YAP pathway and the Wnt/β-catenin pathway.
The study found that SETD7 is an important factor in the association of these pathways. SETD7 is capable of modifying the YAP protein, and YAP plays an important role in activating the Wnt pathway.
Professor Zaph said, "In fact, SETD7 is an important molecular switch that controls two pathways leading to bowel cancer." Zaph and his colleagues found that in the absence of SETD7, the rate of tumor development was significantly delayed. Blocking SETD7 may not completely prevent the development of the tumor, but it can actually delay its development.
This discovery provides a potential new target for the treatment of cancers such as bowel cancer.
Source: Noble
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