Pharmacological effects
1, the role of the central nervous system
Ganoderma lucidum, Ganoderma lucidum fermentation concentrate, mycelium alcohol extract and spore powder after degreasing alcohol extract can reduce the spontaneous activity of mice when injected intraperitoneally.
2, the role of the cardiovascular system
Ganoderma lucidum has a strong heart on the isolated heart, rabbits intraperitoneal injection of Ganoderma lucidum can increase cardiac contractility, heart rate changes, intraperitoneal injection of Ganoderma lucidum alcohol extracts, pituitary chlorophyll caused by high T wave in rabbit ECG Obvious antagonistic effects indicate that it has some resistance to acute myocardial ischemia.
3, anti-platelet aggregation and anti-thrombotic effects
Ganoderma injection significantly inhibited ADP- and collagen-induced platelet aggregation in vitro. Healthy individuals treated with 0.2 g of Gaizhi for a week for a week significantly inhibited ADP-induced platelet aggregation and had a poorer effect on collagen-induced rats. Patients with myocardial infarction or cerebral infarction took Ganoderma for 2 weeks. Both in vitro and in vivo tests were able to inhibit ADP-induced platelet aggregation, and also significantly inhibited thrombosis in vitro after administration.
4, the role of the respiratory system
The experimental results of tracheal phenol red excretion in mice showed that ganoderma alcohol extract and Ganoderma sp. peritoneal injection all had phlegm effect.
5. Effects on metabolism and endocrine function Mice injected intraperitoneally with ganoderma lucidum polysaccharide BN3C (ie D6) can promote the synthesis of protein, nucleic acid in serum, liver and bone marrow, accelerate bone marrow cell division and proliferation, and increase mouse liver homogenate cells. P-450 content increases liver detoxification. Ganoderma extract can increase plasma cortisol levels in burned animals.
6, hepatoprotective effect
Mice fed with Ganoderma lucidum can alleviate liver pathological damage caused by carbon tetrachloride poisoning.
7, the role of experimental muscle rigidity
Intraperitoneal injection of Ganoderma lucidum injection in mice caused a significant decrease in aldolase activity in experimental muscle rigidity caused by 2,4-dichlorophenoxyacetic acid.
8, anti-oxidation, anti-aging effects Ganoderma lucidum polysaccharides GLA, GLB, GLC on superoxide anion (O) free radical production and red cell lipid peroxidation are inhibited, and hydroxyl radical (· OH) scavenging effect, Superoxide dismutase-like activity is an important factor in retarding senescence in ganoderma.
9, anti-inflammatory effect
Rats fed artificial and natural Ganoderma lucidum decoction liquor concentrates can significantly inhibit carrageenan-induced joint swelling.
10. Anti-tumor effect
Ganoderma lucidum fruiting body handle extract has an 87.6% inhibition rate on mouse S180, and its components contain polysaccharides and proteins. Ganoderma lucidum was extracted from the hot water extract of a variety of polysaccharide intraperitoneally, inhibiting the mouse S180 transplantable tumor. Orally invalid.
11, immune regulation
The intraperitoneal injection of proteoglycan isolated from Ganoderma lucidum can increase the number of cells, macrophages, and polymorphonuclear leukocytes in the peritoneal exudate of mice, indicating an immunopotentiating effect on the spleen hemolysis plaque of mice immunized with sheep red blood cells (SRBC). The number of formed cells increased significantly and this polysaccharide contained galactose, glucose and xylose.
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