Refrigerant
Vapor compression refrigeration uses the inside of the refrigerant as its working fluid. There are many choices of refrigerants, and when a cooler is selected, the application of the cooling temperature is matched to the refrigeration characteristics of the refrigerant. The important parameters to consider are the operating temperature and pressure.
There are several environmental concerns about refrigerants that also affect the future availability of the unit's applications. This is an intermittent application mainly considering that large chillers may last for more than 25 years. Ozone Depletion Potential (ODP) and Global Warming Potential (GWP) refrigerants need to be considered. Potential and some common water vapor data compression refrigerants with some GWP values:
| Refrigerant | Ozone depletion potential | Global warming potential |
| R-134a | 0 | 1300 |
| R-123 | 0.012 | 120 |
| R-22 | 0.05 | 1700 |
| R401a | 0.027 | 970 |
| R404a | 0 | 3260 |
| R407a | 0 | |
| R407c | 0 | 1525 |
| R408a | 0.016 | 3020 |
| R409a | 0.039 | 1290 |
| R410a | 0 | 1725 |
| R500 | 0.7 | |
| R502 | 0.18 | 5600 |
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