Release date: 2009-06-30
Recently, Taiwan Ocean University, Taiwan University of Science and Technology and other units jointly developed the world's first DNA vaccine patch. In the future, people don't have to go to the hospital to vaccinate. Just stick the vaccine patch on the arm at home to prevent disease. effect.
It is understood that the DNA vaccine patch is quite stable, can be stored at room temperature, and arbitrarily attached to each part of the arm, and then posted one tablet after three weeks, two tablets can appear immune effect. Because it is painless and convenient, everyone can operate at home and the market potential is endless.
The researchers said that the vaccine types are divided into two categories: traditional vaccines and biotech vaccines. DNA vaccines are genetic vaccines. The main immunization route of DNA vaccine is usually to send DNA into the body through intramuscular injection or gene gun, but intramuscular injection will inevitably hurt. Children and adults have so-called "needle fear", and it is estimated that every 100 injections In this case, 5 serious injection injuries will occur.
DNA is a molecule larger than protein, and it is difficult to penetrate the skin and enter the body; even if it is barely enter the body, it is easily broken down by DNA enzymes (DNase). They use the characteristics of positively charged micro-lipids and negatively charged DNA to encapsulate the DNA vaccine with micro-lipids, and overcome the limitations to deliver DNA vaccines into the body. The stratum corneum on the surface of the skin will block many foreign things, so the DNA vaccine coated with the liposome can be transdermally transported into the body as long as the stratum corneum is removed through the fruit acid. The cell membrane structure of the liposome and the skin is similar. Both are double-layer phospholipids. The liposome can be combined with the cell membrane to easily bring the DNA vaccine into the epidermal cells, exhibiting the vaccine antigen, and triggering the immune response to prevent disease. .
At present, the research team is developing a DNA vaccine patch for Japanese encephalitis virus, which is expected to be transferred to the biotech company on the island for mass production. In the future, it will be directed to influenza virus, enterovirus, dengue fever, avian influenza and SARS. Vaccine patch efforts.
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