Release date: 2015-10-15
Recently, Wu Zhengyan, a researcher at the Institute of Bioenergy and Materials Research, Institute of Technology, Biological and Agricultural Engineering, Hefei Institute of Material Science, Chinese Academy of Sciences, is aiming at some of the problems in current cancer treatment, with the Strong Magnetic Field Science Center, Anhui Medical University, and Anhui Agricultural University. Researchers at the University of Pennsylvania have collaborated on the development of new drug carriers and MR contrast agents, and have made progress in the series. Related results published in
Advanced Functional Materials (2015, 25, 6101-6111), ACS Applied Materials & Interfaces (2015, 7, 14192-14200; 2015, 7, 16837-16841; 2014, 6, 8042-8047) and Particle & Particle Systems Characterization ( 201
4, 31, 976-984) and other journals. The research team used porous materials as a chemotherapeutic drug carrier, organically functionalized it, and then grafted the targeting ligand and magnetic resonance imaging contrast agent, which significantly enhanced the magnetic resonance imaging effect and drug targeted transmission ability, in order to achieve visualization. The purpose of treating tumors. At the same time, the researchers used a DNA bioactive molecule extracted from plants as an encapsulant for porous materials and modified it to develop a drug-controlled release system sensitive to DNaseI enzyme, which can significantly improve chemotherapy drugs. The drug effect reduces the damage of the drug to normal cells.
Some current studies have shown that the surrounding environment of tumor cells is weakly acidic. The researchers developed a pH-sensitive drug delivery system and introduced a dual-mode imaging model into the system. The researchers prepared a nano-sized Gd/Fe3O4-doped dual-mode magnetic resonance contrast agent, and organically functionalized the contrast agent to load the chemotherapy drug through a pH-sensitive chemical bond. When the drug-loaded nanoparticles reach the tumor site, the chemical bond of the drug-loaded drug is broken, and the drug is gradually released to kill the tumor cells. Animal experiments have shown that the system has good tumor suppressing effect and magnetic resonance imaging effect, which provides the possibility to visually monitor the treatment of tumors.
In addition, the researchers successfully implemented the detection of small molecules such as boric acid with the development of functionalized contrast agent properties.
The research work was supported by the National Major Instrument Development Project of the Ministry of Science and Technology and the National Natural Science Foundation.
Source: Hefei Research Institute
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